multi-well microelectrode plates Search Results


multi-well microelectrode plates  (Axion BioSystems)
90
Axion BioSystems multi-well microelectrode plates
Multi Well Microelectrode Plates, supplied by Axion BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/multi-well microelectrode plates/product/Axion BioSystems
Average 90 stars, based on 1 article reviews
multi-well microelectrode plates - by Bioz Stars, 2026-03
90/100 stars
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multi-well microelectrode (mwmea) plates  (Axion BioSystems)
90
Axion BioSystems multi-well microelectrode (mwmea) plates
A total of 1055 unique compounds from EPA’s ToxCast Phase 2 libraries were screened at a single concentration (40 μM) in <t>primary</t> <t>cortical</t> <t>cultures</t> grown on mwMEA plates to determine acute (40 min) effects on neural network function. Top: A total of 325 compounds altered network firing rates (MFR) beyond threshold with 308 compounds decreasing activity. In addition to decreasing activity, 8 of these compounds were also cytotoxic. A total of 18 compounds (including bicuculline methiodide) increased MFR, while 730 compounds did not alter MFR beyond either threshold. Middle: Of the 326 compound identified as hits in the mwMEA assay, 253 compounds (~78%) were categorized for use in five major categories within ToxCast. These categories were pesticides (52), pharmaceuticals (86), fungicides (48), herbicides (35), and chemical intermediates (32). Bottom: A total of 121 compounds (including bicuculline methiodide) out of the 326 total hits could be assigned to gene targets or modes of action (Supplemental Table 4). Shown here are any target genes/MOAs that contained 5 or more compounds, and the total number of compounds assigned to that category. Of the 205 compounds not represented, 87 did not have an assigned target gene/MOA in CPCat.
Multi Well Microelectrode (Mwmea) Plates, supplied by Axion BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/multi-well microelectrode (mwmea) plates/product/Axion BioSystems
Average 90 stars, based on 1 article reviews
multi-well microelectrode (mwmea) plates - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

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A total of 1055 unique compounds from EPA’s ToxCast Phase 2 libraries were screened at a single concentration (40 μM) in primary cortical cultures grown on mwMEA plates to determine acute (40 min) effects on neural network function. Top: A total of 325 compounds altered network firing rates (MFR) beyond threshold with 308 compounds decreasing activity. In addition to decreasing activity, 8 of these compounds were also cytotoxic. A total of 18 compounds (including bicuculline methiodide) increased MFR, while 730 compounds did not alter MFR beyond either threshold. Middle: Of the 326 compound identified as hits in the mwMEA assay, 253 compounds (~78%) were categorized for use in five major categories within ToxCast. These categories were pesticides (52), pharmaceuticals (86), fungicides (48), herbicides (35), and chemical intermediates (32). Bottom: A total of 121 compounds (including bicuculline methiodide) out of the 326 total hits could be assigned to gene targets or modes of action (Supplemental Table 4). Shown here are any target genes/MOAs that contained 5 or more compounds, and the total number of compounds assigned to that category. Of the 205 compounds not represented, 87 did not have an assigned target gene/MOA in CPCat.

Journal: Archives of toxicology

Article Title: Screening the ToxCast Phase II Libraries for Alterations in Network Function using Cortical Neurons Grown on Multi-well Microelectrode Array (mwMEA) Plates

doi: 10.1007/s00204-017-2035-5

Figure Lengend Snippet: A total of 1055 unique compounds from EPA’s ToxCast Phase 2 libraries were screened at a single concentration (40 μM) in primary cortical cultures grown on mwMEA plates to determine acute (40 min) effects on neural network function. Top: A total of 325 compounds altered network firing rates (MFR) beyond threshold with 308 compounds decreasing activity. In addition to decreasing activity, 8 of these compounds were also cytotoxic. A total of 18 compounds (including bicuculline methiodide) increased MFR, while 730 compounds did not alter MFR beyond either threshold. Middle: Of the 326 compound identified as hits in the mwMEA assay, 253 compounds (~78%) were categorized for use in five major categories within ToxCast. These categories were pesticides (52), pharmaceuticals (86), fungicides (48), herbicides (35), and chemical intermediates (32). Bottom: A total of 121 compounds (including bicuculline methiodide) out of the 326 total hits could be assigned to gene targets or modes of action (Supplemental Table 4). Shown here are any target genes/MOAs that contained 5 or more compounds, and the total number of compounds assigned to that category. Of the 205 compounds not represented, 87 did not have an assigned target gene/MOA in CPCat.

Article Snippet: Prior to plating rat primary cortical cultures, multi-well microelectrode (mwMEA) plates from Axion Biosystems Inc. (Atlanta, GA) were prepared for culture by coating with polyethyleneamine as previously described ( Valdivia et al., 2014 ).

Techniques: Concentration Assay, Activity Assay, Pesticides